Buy Imitrex No Prescription > Purchase Imitrex From Trusted Pharmacy
buy imitrex injection no prescriptionbuying sumatriptan online
buy sumatriptan tablets
buying imitrex in mexico
sumatriptan with no prescription
>>> Buy Imitrex Now! Cheapest Price Guaranteed <<<
INFOMATION:
Sumatriptan Systematic (IUPAC) name 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]- N-methyl-methanesulfonamide Clinical data Trade names Imitrex, Imigran,Treximet AHFS/Drugs.com monograph Licence data US FDA:link Pregnancy cat. C Legal status ℞-only (US) Routes tablet, subcutaneous injection, nasal spray Pharmacokinetic data Bioavailability 15% (oral)/ 96% (s.c) Protein binding 14–21% Metabolism MAO Half-life 2.5 hours Excretion 60% urine; 40% feces Identifiers CAS number 103628-46-2 Y ATC code N02CC01 PubChem CID 5358 IUPHAR ligand 54 DrugBank DB00669 ChemSpider 5165 Y UNII 8R78F6L9VO Y KEGG D00451 Y ChEBI CHEBI:10650 Y ChEMBL CHEMBL128 Y Chemical data Formula C14H21N3O2S Mol. mass 295.402 g/mol SMILES O=S(=O)(NC)Cc1cc2c(cc1)ncc2CCN(C)C InChI InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3 Y Key:KQKPFRSPSRPDEB-UHFFFAOYSA-N Y
Adverse effects
Large doses of sumatriptan can cause sulfhemoglobinemia, a rare condition in which the blood changes from red to greenish-black, due to the integration of sulfur into the hemoglobin molecule. If sumatriptan is discontinued, the condition reverses within a few weeks.
Serious cardiac events, including some that have been fatal, have occurred following the use of sumatriptan injection or tablets. Events reported have included coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia, and ventricular fibrillation.[citation needed]
The most common side-effects reported by at least 2% of patients in controlled trials of sumatriptan (25, 50, and 100 mg tablets) for migraine are atypical sensations (paresthesias and warm/cold sensations) reported by 4% in the placebo group and 5–6% in the sumatriptan groups, pain and other pressure sensations (including chest pain) reported by 4% in the placebo group and 6–8% in the sumatriptan groups, neurological events (vertigo) reported by less than 1% in the placebo group and less than 1% to 2% in the sumatriptan groups. Malaise/fatigue occurred in less than 1% of the placebo group and 2–3% of the sumatriptan groups. Sleep disturbance occurred in less than 1% in the placebo group to 2% in the sumatriptan group.
Mechanism of action
Sumatriptan is structurally similar to serotonin (5HT), and is a 5-HT (types 5-HT1D and 5-HT1B) agonist. The specific receptor subtypes it activates are present on the cranial arteries and veins. Acting as an agonist at these receptors, sumatriptan reduces the vascular inflammation associated with migraines.
The specific receptor subtype it activates is present in the cranial and basilar arteries. Activation of these receptors causes vasoconstriction of those dilated arteries. Sumatriptan is also shown to decrease the activity of the trigeminal nerve, which, it is presumed, accounts for sumatriptan's efficacy in treating cluster headaches. The injectable form of the drug has been shown to abort a cluster headache within fifteen minutes in 96% of cases.
Pharmacokinetics
Sumatriptan is administered in several forms; tablets, subcutaneous injection, and nasal spray. Oral administration (as succinate) suffers from poor bioavailability, partly due to presystemic metabolism—some of it gets broken down in the stomach and bloodstream before it reaches the target arteries. A new rapid-release tablet formulation has the same bioavailability, but the maximum concentration is achieved on average 10–15 minutes earlier. When injected, sumatriptan is faster-acting (usually within 10 minutes), but the effect lasts for a shorter time. Sumatriptan is metabolised primarily by monoamine oxidase A into an indole acetic acid analogue, part of which is further conjugated with glucuronic acid. These metabolites are excreted in the urine and bile. Only about 3% of the active drug may be recovered unchanged.
There is no simple, direct relationship between sumatriptan concentration (pharmacokinetics) per se in the blood and its anti-migraine effect (pharmacodynamics). This paradox has, to some extent, been resolved by comparing the rates of absorption of the various sumatriptan formulations, rather than the absolute amounts of drug that they deliver.
sumatriptan to buy
sumatriptan mail order
sumatriptan cheap online
can you buy sumatriptan over the counter
buy sumatriptan succinate injection
order imitrex no prescription
buy sumatriptan succinate
buy sumatriptan succinate
buy imitrex online without prescription
buy imitrex injections online
where can i buy sumatriptan tablets
purchase sumatriptan injection
buy imitrex online without prescription
cheap sumatriptan no prescription
purchase imitrex
can you buy imitrex in mexico
sumatriptan without prescription
buy robaxin 750 mg
purchase generic imitrex
imitrex no prescription needed
imitrex no prescription needed
buy sumatriptan
can you buy imitrex in mexico
sumatriptan 100 mg no prescription
buy zithromax in us
buy sumatriptan 50mg
buy cheap imitrex
sumatriptan online no prescription
buy cheap imitrex online
buy sumatriptan 100 mg
sumatriptan 100 mg no prescription
buy sumatriptan online uk
buy sumatriptan injection
buy cheap imitrex online
buy sumatriptan succinate
cheapest generic imitrex
buy sumatriptan australia
RELATED LINKS:
buy famciclovir 125 mg
order imitrex from canada
